Ethanol → 4-(Benzyloxy)benzoic acid

HRID 866389

Reaktionsgleichung

Reaktionsgleichung von HRID 866389
N[C:2]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)=[O:3].C([OH:20])C>[OH-].[Na+]>[C:2]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([OH:20])=[O:3]

Komponenten

4

Edukt 2

HCID 702EthanolHCID 27264314-Benzyloxybenzamide

Produkt 1

HCID 738804-(Benzyloxy)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A mixture of 4-aminocarbonylphenoxy phenyl methane (10g) in ethanol (100ml) and sodium hydroxide (100ml., 10N) was heated under reflux with vigorous stirring for 24hrs. The reaction mixture was cooled, the precipitated sodium salt was filtered off washed with a little water then converted to 4-carboxyphenoxy phenyl methane by boiling under reflux with concentrated hydrochloric acid (100ml) for 6hr. Dilution of the cooled mixture and extraction with ether yielded 4-carboxyphenoxy phenyl methane, m.p. 188°.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe precipitated sodium salt was filtered off
  5. washwashed with a little water
  6. temperatureunder reflux with concentrated hydrochloric acid (100ml) for 6hr
  7. extractionDilution of the cooled mixture and extraction with ether

Quellen und Nachweise

ORD-Eintrag
ord-628d7530e92b4426b5db4ef6ae9a0596
Quelldatensatz
uspto-grants-1978_07
Patentnummer
US04098816

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