Piperidine → HCID 178431711, Verbindung

Reaktionsgleichung

C1CCNCC1.CC1(C)OC(=O)C(Oc2ccc(Br)cn2)=C1c1ccc(S(C)(=O)=O)cc1>CS(C)=O.O=C(O)C(=O)Nc1c(F)cccc1S(=O)(=O)N1CCCCC1.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>CC1(C)OC(=O)C(Oc2ccc(N3CCCCC3)cn2)=C1c1ccc(S(C)(=O)=O)cc1

Komponenten

Reaktionsbedingungen

Temperatur: 80 °C

Aufarbeitung

additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
aliquot25 microliter of resulting solution is taken
additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Quellen und Nachweise

ORD-Eintrag: ord-a6a1661c85f6470bb1c55ba2ff78546a
Quelldatensatz: Figure 4 from Chemistry informer libraries
DOI: 10.1039/C5SC04751J
Originallink: Quelle ansehen

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Komponenten

Edukt 2

HCID 8082Piperidine

HCID 99328283-((5-Bromopyridin-2-yl)oxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

Produkt 1

HCID 178431711HCID 178431711, VerbindungAusbeute 7,8 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 62657Potassium Phosphate, TribasicReagenz

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)Katalysator

HCID 1242030262-Fluoro-6-(piperidine-1-sulfonyl)anilino(oxo)acetic acidKatalysator

HCID 679Dimethyl SulfoxideLösungsmittel2×

Reaktionsbedingungen

Temperatur: 80 °C

Aufarbeitung

additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
aliquot25 microliter of resulting solution is taken
additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Quellen und Nachweise

ORD-Eintrag: ord-a6a1661c85f6470bb1c55ba2ff78546a
Quelldatensatz: Figure 4 from Chemistry informer libraries
DOI: 10.1039/C5SC04751J
Originallink: Quelle ansehen

Notizen zur Reaktion

Wird geladen…