Piperidine → HCID 178499397, Verbindung

HRID 867330Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 867330
C1CCNCC1.COC(=O)CC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23>CS(C)=O.O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>COC(=O)CC1CCc2cc(N3CCCCC3)cc3[nH]c(=O)c(=O)n1c23

Komponenten

7

Edukt 2

HCID 8082PiperidineHCID 10066635Methyl 2-(9-bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrido[1,2,3-de]quinoxalin-5-yl)acetate

Produkt 1

HCID 178499397HCID 178499397, VerbindungAusbeute 2 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 62657Potassium Phosphate, TribasicReagenzHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)KatalysatorHCID 1188645142-[3,5-Bis(trifluoromethyl)anilino]-2-oxo-acetic acidKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Aufarbeitung

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Quellen und Nachweise

ORD-Eintrag
ord-5657c90b4fed4903a8cce5a90b4a2167
Quelldatensatz
Figure 4 from Chemistry informer libraries
Originallink
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