Ammonia → HCID 19980851, Verbindung

HRID 867941Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 867941
[NH3:1].O=[C:3]([CH3:11])[CH2:4][C:5]([O:7][CH2:8][CH2:9][OH:10])=[O:6]>C(O)C>[NH2:1]/[C:3](/[CH3:11])=[CH:4]\[C:5]([O:7][CH2:8][CH2:9][OH:10])=[O:6]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 118544Butanoic acid, 3-oxo-, 2-hydroxyethyl ester

Produkt 1

HCID 19980851HCID 19980851, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Anhydrous ammonia gas was bubbled through a solution of 2-hydroxyethyl 3-oxo-butyrate (25 g, 0.17 moles) (ref 5) and ethanol (250 mL) for 20 minutes. This solution was stirred for 16 hours at room temperature. The solvent was removed in vacuo and the resulting oil was chromatographed on silica gel (250 g) using etyl acetate-hexane 60:40 as eluant. The enriched fractions were combined and the solvent removed in vacuo to give the product; H' NMR CDCl3 4.33 (t, 2H) 3.85 (t, 2H) 3.55 (s, 1H) 2.85 (broad singlet, 1H) 2.31 (s, 3H).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe resulting oil was chromatographed on silica gel (250 g)
  3. customthe solvent removed in vacuo
  4. customto give the product

Quellen und Nachweise

ORD-Eintrag
ord-fe2403b9755f4cf5b8c3991761bf7c55
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04777167

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