Semicarbazide hydrochloride → HCID 178497445, Verbindung
Reaktionsgleichung
[CH:1]([N:4]([CH:22]([CH3:24])[CH3:23])[CH2:5][CH2:6][N:7]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][C:16]=2[C:18]([O:20][CH3:21])=[O:19])[C:10](=O)[C:8]1=[O:9])([CH3:3])[CH3:2].Cl.[NH2:26][NH:27][C:28]([NH2:30])=[O:29]>>[CH:1]([N:4]([CH:22]([CH3:24])[CH3:23])[CH2:5][CH2:6][N:7]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][C:16]=2[C:18]([O:20][CH3:21])=[O:19])/[C:10](=[N:26]/[NH:27][C:28]([NH2:30])=[O:29])/[C:8]1=[O:9])([CH3:3])[CH3:2]Komponenten
3
Versuchsvorschrift
By using methyl 1-(2-diisopropylaminoethyl)-7-isatincarboxylate and semicarbazide hydrochloride, a method analogous to that described in Example 6 was carried out, and the reaction product was purified with silica gel column chromatography (eluent: chloroform/ethanol=20/1) and then recrystallized from chloroform-hexane to obtain (Z)-1-(2-diisopropylaminoethyl)-7-methoxycarbonylisatin 3-semicarbazone having a melting point of 192°-195° C. (yield: 28.1%).
Aufarbeitung
- customthe reaction product was purified with silica gel column chromatography (eluent: chloroform/ethanol=20/1)
- customrecrystallized from chloroform-hexane