2-(Bromomethyl)pyridine hydrobromide → HCID 58755925, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:4]=1[CH2:5][C:6]1[NH:7][C:8](=[S:11])[NH:9][N:10]=1.Br.Br[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1>>[CH3:1][O:2][C:3]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:4]=1[CH2:5][C:6]1[NH:10][N:9]=[C:8]([S:11][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[N:7]=1Komponenten
3
Versuchsvorschrift
Prepared in a similar manner to example 1 using 5-(2,4-dimethoxybenzyl)-2H-1,2,4-triazole-3(4H)-thione (example 9a) and 2-(bromomethyl)pyridine hydrobromide. Yield 34%. 1H NMR (500 MHz, CDCl3): δ 3.77 (s, 3H), 3.79 (s, 3H), 4.0 (s, 2H), 4.34 (s,2H), 6.35-6.45 (m, 2H), 7.1 (d, 1H), 7.15 (t, 1H), 7.3 (d, 1H), 7.7 (t, 1H), 8.5 (s, 1H). MS(M+H, 343).
Quellen und Nachweise
- ORD-Eintrag
- ord-318b5990ab234c498993d0522586ba27
- Quelldatensatz
- uspto-grants-2015_03