Aluminium lithium hydride → (4-Phenyl-1,3-thiazol-2-yl)methanol

HRID 868927Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 868927
[C:1]1([C:7]2[N:8]=[C:9]([C:12](OCC)=[O:13])[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[C:1]1([C:7]2[N:8]=[C:9]([CH2:12][OH:13])[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 24730326Ethyl 4-phenyl-1,3-thiazole-2-carboxylate

Produkt 1

HCID 698895(4-Phenyl-1,3-thiazol-2-yl)methanolAusbeute 109,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To ethyl 4-phenylthiazole-2-carboxylate (1 g, 4.3 mmol) in anhydrous THF was added LiAlH4 and the mixture was stirred for 1 hour. The reaction was quenched with water, extracted with EtOAc and dried over anhydrous sodium sulfate. The solution was concentrated under vacuum to afford (4-phenylthiazol-2-yl)methanol as a white solid (0.9 g). MS (ESI) m/z 191 (M+H+).

Aufarbeitung

  1. customThe reaction was quenched with water
  2. extractionextracted with EtOAc
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationThe solution was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2e11ec2db35248658c21fc491d8be895
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969349B2

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