Lithium Chloride → HCID 178509968, Verbindung

HRID 869080Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869080
I[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([F:10])[CH:3]=1.C([Mg:14][Cl:15])(C)C.[Li+].[Cl-]>C1COCC1>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([Mg:14][Cl:15])=[CH:3][C:4]=1[F:10])#[N:7]

Komponenten

5

Edukt 3

HCID 433294Lithium ChlorideHCID 27745182-Fluoro-4-iodobenzonitrileHCID 178418918HCID 178418918, Verbindung

Produkt 1

HCID 178509968HCID 178509968, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 4-iodo-2-fluorobenzonitrile (2.5 g, 10.12 mmol) in 10.12 ml THF under argon, a solution of isopropylmagnesium chloride. LiCl in THF (10.12 ml, 13.16 mmol) was added at 0° C. The reaction mixture was stirred at this temperature for 5 min to afford the title compound, which was used immediately in the next step as a stock solution (˜0.5M in THF).

Quellen und Nachweise

ORD-Eintrag
ord-97e332776eee4adda06df08c52199f0f
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969341B2

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