Ethyl 2-(benzyloxy)-3-oxopropanoate → HCID 178517543, Verbindung

HRID 869302

Reaktionsgleichung

Reaktionsgleichung von HRID 869302
[CH2:1]([O:8][CH:9]([CH:15]=O)[C:10]([O:12]CC)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:23]=[C:22]([C:24](=[NH:26])[NH2:25])[CH:21]=[CH:20][N:19]=1>C(O)C>[CH2:1]([O:8][C:9]1[C:10]([OH:12])=[N:25][C:24]([C:22]2[CH:21]=[CH:20][N:19]=[C:18]([Cl:17])[CH:23]=2)=[N:26][CH:15]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 19903223Ethyl 2-(benzyloxy)-3-oxopropanoateHCID 509886352-Chloropyridine-4-carboximidamide

Produkt 1

HCID 178517543HCID 178517543, VerbindungAusbeute 66 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of crude ethyl 2-(benzyloxy)-3-oxopropanoate (all from previous step), 2-chloropyridine-4-carboximidamide (9.57 g, 50 mmol) and 100 mL of anhydrous ethanol was refluxed for 4 h under nitrogen. The mixture was then cooled and the volatile solvents were removed by rotary-evaporator. The residue was re-dissolved in water and filtered. The filtrate was acidified by HCl (4N aq) in an ice bath and the white precipitate was filtered, washed with water, and dried to give 5-(benzyloxy)-2-(2-chloropyridin-4-yl)pyrimidin-4-ol (10.4 g, 66%). 1HNMR δ (400 MHz, d6-DMSO): 13.12 (s, 1H), 8.58 (d, J=5.2 Hz, 1H), 8.12 (s, 1H), 8.04 (d, J=5.2 Hz, 1H), 7.94 (s, 1H), 7.51-7.34 (m, 5H), 5.20 (s, 2H); MS (ESI) m/z (M+H)+ 314.

Aufarbeitung

  1. temperaturewas refluxed for 4 h under nitrogen
  2. temperatureThe mixture was then cooled
  3. customthe volatile solvents were removed by rotary-evaporator
  4. dissolutionThe residue was re-dissolved in water
  5. filtrationfiltered
  6. customThe filtrate was acidified by HCl (4N aq) in an ice bath
  7. filtrationthe white precipitate was filtered
  8. washwashed with water
  9. customdried

Quellen und Nachweise

ORD-Eintrag
ord-404d1e1d29a3455a8438780e12d045c9
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969364B2

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