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Cesium carbonate → HCID 67286074, Verbindung

HRID 869335
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 869335
C(=O)([O-])[O-].[Cs+].[Cs+].[Cl:7][C:8]1[CH:9]=[C:10](/[CH:14]=[CH:15]/B2OC(C)(C)C(C)(C)O2)[CH:11]=[CH:12][CH:13]=1.[C:25]([O:29][C:30]([N:32]1[CH2:37][CH2:36][C:35]2[N:38]([CH3:48])[C:39]([C:41]3[CH:46]=[CH:45][N:44]=[C:43](I)[N:42]=3)=[CH:40][C:34]=2[C:33]1=[O:49])=[O:31])([CH3:28])([CH3:27])[CH3:26]>O1CCOCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:25]([O:29][C:30]([N:32]1[CH2:37][CH2:36][C:35]2[N:38]([CH3:48])[C:39]([C:41]3[CH:46]=[CH:45][N:44]=[C:43](/[CH:15]=[CH:14]/[C:10]4[CH:11]=[CH:12][CH:13]=[C:8]([Cl:7])[CH:9]=4)[N:42]=3)=[CH:40][C:34]=2[C:33]1=[O:49])=[O:31])([CH3:28])([CH3:27])[CH3:26]
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 3

HCID 10796Cesium carbonateHCID 162181612-[(E)-2-(3-Chlorophenyl)ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 86667879HCID 86667879, Verbindung

Produkt 1

HCID 67286074HCID 67286074, VerbindungAusbeute 50 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418397
HCID 178418397, Verbindung
Katalysator
HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Cesium carbonate (0,143 g, 0.438 mmol), palladium tetrakis (0.051 g, 0.042 mmol) and 2-[(E)-2-(3-Chloro-phenyl)-vinyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (0.116 g, 0.440 mmol) were added to a solution of 2-(2-Iodo-pyrimidin-4-yl)-1-methyl-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (synthesised as reported in Example 9) (0.100 g, 0.22 mmol) in dioxane (5.0 ml) under argon atmosphere. Argon was bubbled for 5 minutes, the vial was closed and the reaction mixture was heated by microwave irradiation for 30 minute at 100° C. for two cycles. In order to affect completion, a refresh of the catalyst and the base and two more cycles at the microwaves were carried on. The solvent was removed under vacuum, the residue was taken into DCM (5.0 ml), which was washed with a saturated solution of NaHCO3 (1×5.0 ml), brine (1×5.0 ml), and it was dried over Na2SO4. The filtrate was evaporated to dryness to give the crude product, which was purified by flash chromatography, over silica gel, using DCM/MeOH (9.9:0.1) as eluent, to afford 2-{2-[(E)-2-(3-Chloro-phenyl)-vinyl]-pyrimidin-4-yl}-1-methyl-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester yellow solid (0.051 g, 0.110 mmol, 50%).

Aufarbeitung

  1. customArgon was bubbled for 5 minutes
  2. customthe vial was closed
  3. customThe solvent was removed under vacuum
  4. washwas washed with a saturated solution of NaHCO3 (1×5.0 ml), brine (1×5.0 ml), and it
  5. dry with materialwas dried over Na2SO4
  6. customThe filtrate was evaporated to dryness
  7. customto give the crude product, which
  8. customwas purified by flash chromatography, over silica gel

Quellen und Nachweise

ORD-Eintrag
ord-3d69bd6560284adbb652333e10cbc225
Quelldatensatz
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08969366B2

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