Lithium borohydride → HCID 21914755, Verbindung

HRID 869396Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869396
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:16])[CH:13]([CH3:15])[CH3:14])[S:9][CH:10]=1)=O)C.[Li+].[BH4-]>C1COCC1>[C:12]([NH:11][C:8]1[S:9][CH:10]=[C:6]([CH2:4][OH:3])[N:7]=1)(=[O:16])[CH:13]([CH3:15])[CH3:14]

Komponenten

4

Edukt 2

HCID 4148881Lithium borohydrideHCID 21914754HCID 21914754, Verbindung

Produkt 1

HCID 21914755HCID 21914755, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

11B (0.73 g, 3 mmol) was dissolved in THF (14 mL). To the solution was added LiBH4 (0.23 g, 10 mmol) in batches at room temperature. The reaction mixture was refluxed overnight, then quenched with 14 mL of anhydrous MeOH and concentrated to dryness. The residue was dissolved in dichloromethane and filtered. The filtrate was concentrated and dried to give a crude product 11C (0.48 g, 100% yield).

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed overnight
  2. customquenched with 14 mL of anhydrous MeOH
  3. concentrationconcentrated to dryness
  4. dissolutionThe residue was dissolved in dichloromethane
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9fc6cc235f2d4b5d9850ea158d98f2e9
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969373B2

Notizen zur Reaktion

Wird geladen…