Hydrochloric Acid → HCID 86722249, Verbindung

HRID 869404Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869404
[Br:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10]C(C)=O)[CH:5]=[CH:4][C:3]=1[O:14][C:15]([CH3:17])=[O:16].CO.C([O-])([O-])=O.[K+].[K+].Cl>ClCCl>[C:15]([O:14][C:3]1[CH:4]=[CH:5][C:6]([OH:10])=[C:7]([C:8]#[N:9])[C:2]=1[Br:1])(=[O:16])[CH3:17]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 11430Potassium CarbonateHCID 86722248HCID 86722248, Verbindung

Produkt 1

HCID 86722249HCID 86722249, VerbindungAusbeute 62,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

12C (15 g, 0.05 mol) was added to MeOH (52 ml) and dichloromethane (52 mL). To the mixture was added K2CO3 (7 g, 0.05 mol) in batches at room temperature. The reaction mixture was stirred overnight at room temperture, then neutralized with diluted hydrochloric acid to pH=6˜7, extracted with dichloromethane, dried over anhydrous Na2SO4 and concentrated to give 12D (8 g, 62.1% yield).

Aufarbeitung

  1. extractionextracted with dichloromethane
  2. dry with materialdried over anhydrous Na2SO4
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-079f798c7ac44463a7e558471894e8f8
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969373B2

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