Aluminium lithium hydride → HCID 71744071, Verbindung

HRID 869477Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 869477
[N:1]1[CH:2]=[C:3]([C:10](OCC)=[O:11])[N:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[N:5]2.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[N:1]1[CH:2]=[C:3]([CH2:10][OH:11])[N:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[N:5]2

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 71744070Ethyl imidazo[1,2-B]pyridazine-3-carboxylate

Produkt 1

HCID 71744071HCID 71744071, VerbindungAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of ethyl imidazo[1,2-b]pyridazine-3-carboxylate (1.91 g, 10 mmol) in anhydrous THF (20 mL), lithium aluminium hydride (1.34 g, 35 mmol) was added in portions over 15 min. After stirring at RT for 16 h, the mixture was quenched with ice-water (20 mL) and then extracted with ethyl acetate (30 mL×2). The combined organic layers were washed with brine, dried over Na2SO4 then filtered. The filtrate was concentrated in vacuo to afford imidazo[1,2-b]pyridazin-3-ylmethanol (0.85 g, 57% yield).

Aufarbeitung

  1. customthe mixture was quenched with ice-water (20 mL)
  2. extractionextracted with ethyl acetate (30 mL×2)
  3. washThe combined organic layers were washed with brine
  4. dry with materialdried over Na2SO4
  5. filtrationthen filtered
  6. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4afacf5250e445019a0d7611ee1548d6
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969363B2

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