Formamidine acetate → HCID 178518231, Verbindung
Reaktionsgleichung
[NH2:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([O:9]CC)=O.C(O)(=O)C.[CH:16](N)=[NH:17]>CCO>[CH:5]1[N:4]=[C:3]2[C:7]([N:17]=[CH:16][NH:1][N:2]2[CH:6]=1)=[O:9]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of ethyl 1-amino-1H-imidazole-2-carboxylate (800 mg, 5.16 mmol, 1.0 eq) and formamidine acetate (2.68 g, 25.78 mmol, 5.0 eq) in EtOH (100 mL) was stirred at reflux overnight. The resulting mixture was cooled to RT. The solid was collected by filtration, rinsed with EtOH (3×2 mL) and petroleum ether (2 mL×3), and then dried in vacuo to afford imidazo[1,2-f][1,2,4]triazin-4-ol (400 mg, 50.2% yield).
Aufarbeitung
- temperatureat reflux overnight
- filtrationThe solid was collected by filtration
- washrinsed with EtOH (3×2 mL) and petroleum ether (2 mL×3)
- customdried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-2b8f0d45791742e6a0fb29c9443ca3aa
- Quelldatensatz
- uspto-grants-2015_03
- Patentnummer
- US08969363B2
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