HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Cyclopropyl-1,2-oxazole-3-carboxylic acid → (R)-ethyl 3-((1-(5-cyclopropylisoxazole-3-carbonyl)pyrrolidin-2-yl)methoxy)picolinate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Cyclopropyl-1,2-oxazole-3-carboxylic acid | HCID 1092113 | — |
| Edukt | (R)-ethyl 3-(pyrrolidin-2-ylmethoxy)picolinate | HCID 86666098 | — |
| Edukt | HCID 178493765 | HCID 178493765 | — |
| Produkt | (R)-ethyl 3-((1-(5-cyclopropylisoxazole-3-carbonyl)pyrrolidin-2-yl)methoxy)picolinate | HCID 86666099 | — |
Reaktionsschritte
The title compound was prepared according to the procedure described in Step 5 of EXAMPLE 31 using (R)-ethyl 3-(pyrrolidin-2-ylmethoxy)picolinate bis(trifuluoroacetic acid) salt (EXAMPLE 34 Step 1) and 5-cyclopropylisoxazole-3-carboxylic acid instead of ammonium chloride and 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinic acid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08969383B2 |
| Quelldatensatz | uspto-grants-2015_03 |
| ORD ID | ord-f2c7c4fb741448c9a95c46a0b61d967c |
| Quellennotiz | uspto-grants-2015_03 |