Benzenemethanamine, 2,4-dichloro-N-methyl- → HCID 67455587, Verbindung

HRID 870122

Reaktionsgleichung

Reaktionsgleichung von HRID 870122
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Br:11])[CH:6]=1)=[O:4].[Cl:12][C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=1[CH2:20][NH:21][CH3:22]>O1CCOCC1>[Br:11][C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][N:21]([CH2:20][C:14]2[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:13]=2[Cl:12])[CH3:22])[CH:10]=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 485424Benzenemethanamine, 2,4-dichloro-N-methyl-HCID 5195852-Bromo-1-(3-bromophenyl)ethan-1-one

Produkt 1

HCID 67455587HCID 67455587, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

Into a 1 L 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of 2-bromo-1-(3-bromophenyl)ethanone (55 g, 199.28 mmol, 1.00 equiv) in 1,4-dioxane (300 mL), TEA (40 g, 396.04 mmol, 1.99 equiv), and (2,4-dichlorophenyl)-N-methylmethanamine (38 g, 201.06 mmol, 1.01 equiv). The resulting solution was stirred for 2 h at 25° C. in an oil bath. The solids were filtered out and the filtrate was used without any further purification.

Aufarbeitung

  1. customInto a 1 L 3-necked round-bottom flask purged
  2. temperaturemaintained with an inert atmosphere of nitrogen
  3. filtrationThe solids were filtered out
  4. customthe filtrate was used without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-567080e65a03436d8b495ce9f338ebf1
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969377B2

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