Trifluoroacetic acid → 6-Chloro-5-methylpyridazin-3-amine
Reaktionsgleichung
[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8]CC2C=CC(OC)=CC=2OC)=[CH:4][C:3]=1[CH3:20].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH2:8])=[CH:4][C:3]=1[CH3:20]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of (6-chloro-5-methyl-pyridazin-3-yl)-(2,4-dimethoxy-benzyl)-amine from above (680 mg) in DCM (8 ml) was added TFA (8 ml). The resulting solution was allowed to stand for overnight. The mixture was concentrated to give the titled compound which was used directly for next step.
Aufarbeitung
- concentrationThe mixture was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-4179f113de524718b26d2b53cccacf59
- Quelldatensatz
- uspto-grants-2015_03
- Patentnummer
- US08969565B2
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