Hydrochloric Acid → 4-{[({4-(Aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoic acid

HRID 871010Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 871010
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:22]([C:23]([NH2:25])=[O:24])=[C:21]([NH:26][C:27]([N:29]4[CH2:33][CH2:32][CH2:31][C:30]4=[O:34])=[O:28])[S:20][N:19]=3)=[CH:14][CH:13]=2)=[O:10])=[CH:4][CH:3]=1.Cl.[OH-:36].[Na+]>>[NH2:25][C:23]([C:22]1[C:18]([C:15]2[CH:16]=[CH:17][C:12]([NH:11][C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=3)=[O:10])=[CH:13][CH:14]=2)=[N:19][S:20][C:21]=1[NH:26][C:27]([NH:29][CH2:33][CH2:32][CH2:31][C:30]([OH:34])=[O:36])=[O:28])=[O:24]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 716216293-[4-({[(4-Methylphenyl)amino]carbonyl}amino)phenyl]-5-{[(2-oxopyrrolidin-1-yl)carbonyl]amino}isothiazole-4-carboxamide

Produkt 1

HCID 866892284-{[({4-(Aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoic acid

Versuchsvorschrift

3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-{[(2-oxopyrrolidin-1-yl)carbonyl]amino}isothiazole-4-carboxamide (11.8 g,) was added to 1 N sodium hydroxide (100 mL) at ambient temperature. The resulting mixture was stirred at ambient temperature for overnight (reaction mixture became clear solution). Reaction mixture acidified with 2 N HCl. The solid which formed was collected by filtration and washed with water then dried in vacuo to give the title compound as off white solid (9.1 g, 75%).

Aufarbeitung

  1. custom(reaction mixture became clear solution)
  2. customReaction mixture
  3. customThe solid which formed
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customthen dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-38faf31f64f740be88c0ef555bfa4064
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969583B2

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