Sodium Azide → 3-Azido-2-oxopropanoic acid

HRID 871065Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 871065
Br[CH2:2][C:3](=[O:7])[C:4]([OH:6])=[O:5].[N-:8]=[N+:9]=[N-:10].[Na+]>CS(C)=O>[N:8]([CH2:2][C:3](=[O:7])[C:4]([OH:6])=[O:5])=[N+:9]=[N-:10]

Komponenten

4

Edukt 2

HCID 33557Sodium Azide2×HCID 70684Bromopyruvic Acid

Produkt 1

HCID 866899443-Azido-2-oxopropanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel2×

Versuchsvorschrift

KY-740 3-bromo-2-oxopropanoic acid (1.66 gr, 10 mmol) was added to a solution of sodium azide (0.715 gr, 11 mmol) in DMSO (20 ml) which was prepared by stirring the sodium azide in DMSO at room temperature for 40 min. the mixture reaction was stirred for 2 h at room temperature. It was quenched with water (50 ml). The mixture was extracted with Et2O (3×100 ml). The combined organic layers were washed with water, dried with Na2SO4, filtered, and concentrated in vacuo. Yield 1.1 gr (85%). 1HNMR (400 MHz, DMSO-d6) δ 6.3 (s, 2H). 13C-NMR δ 113.52, 136.31, 165.3.

Aufarbeitung

  1. customwas prepared
  2. customthe mixture reaction
  3. customIt was quenched with water (50 ml)
  4. extractionThe mixture was extracted with Et2O (3×100 ml)
  5. washThe combined organic layers were washed with water
  6. dry with materialdried with Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-dbae15518fb94f328349bfde9de3b5a7
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969573B2

Notizen zur Reaktion

Wird geladen…