Hydrochloric Acid → 5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylic acid

HRID 872479Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 872479
[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:5][C:4]([C:13]([O:15]C)=[O:14])=[CH:3]1.Cl>[OH-].[Na+]>[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:5][C:4]([C:13]([OH:15])=[O:14])=[CH:3]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 2748711methyl 5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylate

Produkt 1

HCID 91673915-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylic acidAusbeute 55,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

Methyl 5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylate (0.35 g; 1.60 mmol) in 5 ml of 2M NaOH solution was heated at 60° C. for 2 h after which the reaction mixture was made acidic with 1.5 ml of concentrated HCl which caused the product to form a yellow precipitate. Filtering gave 0.18 g of the product. 1H-NMR (400 MHz; d6-DMSO): δ 5.97 (s, 1H), 7.33-7.37 (m, 1H), 7.48-7.52 (m, 2H), 7.74 (m, 2H).

Aufarbeitung

  1. customto form a yellow precipitate
  2. filtrationFiltering

Quellen und Nachweise

ORD-Eintrag
ord-7418567edbec4a588aca287db6da9a0b
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08975254B2

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