Sodium Hydroxide → HCID 28806058, Verbindung

HRID 872785Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 872785
[CH:1]([C:4]1[N:8]=[C:7]([C:9]([O:11]CC)=[O:10])[O:6][N:5]=1)([CH3:3])[CH3:2].O[NH:15]/[C:16](=N/[H])/[C:17]1C=CC=NC=1.[OH-].[Na+]>>[N:15]1[CH:16]=[CH:17][CH:2]=[C:1]([C:4]2[N:8]=[C:7]([C:9]([OH:11])=[O:10])[O:6][N:5]=2)[CH:3]=1

Komponenten

4

Edukt 3

HCID 14798Sodium HydroxideHCID 534046373-Isopropyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl esterHCID 178506505HCID 178506505, Verbindung

Produkt 1

HCID 28806058HCID 28806058, Verbindung

Versuchsvorschrift

Following the procedure described in U.S. Pat. No. 5,578,550 for the preparation of ethyl 3-isopropyl-1,2,4-oxadiazole-5-carboxylate, the title product was prepared from (E)—N-hydroxynicotinimidamide (2.727 g, 19.88 mmol) and ethyl oxalyl chloride (2.89 mL, 25.9 mmol) followed by subsequent ester hydrolysis with sodium hydroxide solution according to Example 225(b). Yield 1.32 g. 1H NMR (400 MHz; d6-DMSO): δ 7.63 (m, HA), 8.32 (m, 1H), 8.86 (dd, 1H), 9.03 (dd, 1H).

Quellen und Nachweise

ORD-Eintrag
ord-4e8d11574bb147d5890808d17f26ad31
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08975254B2

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