Hydrochloric Acid → 2-(4-Fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid

HRID 874362Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 874362
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:20]=[C:12]3[CH2:13][CH:14]([C:17]([O-:19])=[O:18])[CH2:15][CH2:16][N:11]3[N:10]=2)=[CH:5][CH:4]=1.[Na+]>>[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:20]=[C:12]3[CH2:13][CH:14]([C:17]([OH:19])=[O:18])[CH2:15][CH2:16][N:11]3[N:10]=2)=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 117776381Sodium 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate

Produkt 1

HCID 839653482-(4-Fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acidAusbeute 40,1 %

Versuchsvorschrift

Concentrated hydrochloric acid (0.16 ml) was added to an aqueous solution (2 ml) of the sodium 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate (530 mg) obtained in (Example 5.2) <Step 2>, and the obtained mixture was then stirred for 15 minutes. Thereafter, the precipitated solid was collected by filtration, so as to obtain the title compound (196 mg) in the form of a whitish brown solid.

Aufarbeitung

  1. customobtained in (Example 5.2) <Step 2>
  2. filtrationThereafter, the precipitated solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-821edcd17fe74db6a0f7230b73df0bed
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08980888B2

Notizen zur Reaktion

Wird geladen…