Thionyl Chloride → 2,6-Dichloro-4-(methylcarbamoyl)benzoyl chloride
Reaktionsgleichung
[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:14])[NH:12][CH3:13])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:14])[NH:12][CH3:13])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4]([Cl:18])=[O:5]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
A mixture of 2,6-dichloro-4-(methylcarbamoyl)benzoic acid (400 mg, 1.6 mmol) and thionyl chloride (1.91 g, 16 mmol) in dichloromethane (10 mL) was stirred at 50° C. for 5 hours. The reaction mixture was concentrated under rotary evaporator and used as such for next step.
Aufarbeitung
- concentrationThe reaction mixture was concentrated under rotary evaporator
Quellen und Nachweise
- ORD-Eintrag
- ord-7bf75a3ddfa543169c0fdcf7e0d18d11
- Quelldatensatz
- uspto-grants-2015_03
- Patentnummer
- US08980911B2
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