Nitric Acid → 5-chloro-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine
Reaktionsgleichung
[Cl:1][C:2]1[C:3]([F:11])=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[N+:12]([O-])([OH:14])=[O:13]>>[Cl:1][C:2]1[C:3]([F:11])=[C:4]2[C:10]([N+:12]([O-:14])=[O:13])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1Komponenten
3
Versuchsvorschrift
5-Chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridine (1.2 g, 7.0 mmol) was added slowly to fuming nitric acid (10 mL) at 0° C. Upon completion of the addition, the reaction was stirred for 10 minutes, and then quenched with ice. Water was added until a precipitate formed, which was filtered, washed with water and dried to give the product 5-chloro-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine (1.3 g, 86% yield).
Aufarbeitung
- additionUpon completion of the addition
- customquenched with ice
- additionWater was added until a precipitate
- customformed
- filtrationwhich was filtered
- washwashed with water
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-f2c5c1708f5c463880228a393026ab5b
- Quelldatensatz
- uspto-grants-2015_03
- Patentnummer
- US08981085B2
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