Isopropanol → 5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine
Reaktionsgleichung
[Cl:1][C:2]1[C:3]([F:14])=[C:4]2[C:10]([N+:11]([O-])=O)=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.CC(O)C>C1COCC1.[Pt]>[Cl:1][C:2]1[C:3]([F:14])=[C:4]2[C:10]([NH2:11])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
5-Chloro-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine (1.00 g, 4.6 mmol) and platinum-0.5% Fe (0.452 g, 0.06 mmol) were suspended in THF (12.4 mL) with IPA (6.2 mL). The mixture was hydrogenated at 20 psi for 20 hours, and then the catalyst was removed by filtration. The filtrate was concentrated to dryness, and 5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine (923 mg, 107% yield) was isolated as a solid.
Aufarbeitung
- customthe catalyst was removed by filtration
- concentrationThe filtrate was concentrated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-1c195bea42cb477180c6fd1f19b7a29e
- Quelldatensatz
- uspto-grants-2015_03
- Patentnummer
- US08981085B2
Notizen zur Reaktion
Wird geladen…