P-Anisidine → N4-Adamant-1-yl-N6-(4-methoxyphenyl)pyrimidine-4,6-diamine

Beteiligte Stoffe

Reaktionsschritte

100 mg of N-adamant-1-yl-6-chloropyrimidin-4-amine, 56 mg of p-anisidine, 73 mg of Na-butylate, 2.2 mg of Pd(OAc)2 and 12 mg of BINAP were taken in a screw cap vial under agron in 4 mL of dry toluene and the vial was kept in a heating block at 150° C. for 12 hours. The mixture obtained was cooled to r.t. and purification was carried out by column chromatography using PE:EtOAc 2:1. N4-Adamant-1-yl-N6-(4-methoxyphenyl)pyrimidine-4,6-diamine was obtained.

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