HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide → N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide | HCID 66701368 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide | HCID 66701397 | — |
Reaktionsschritte
A solution of 1.0 g (2.9 mmol) of N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide in 120 ml of glacial acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. The product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 657 mg (50% pure).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08987248B2 |
| Quelldatensatz | uspto-grants-2015_03 |
| ORD ID | ord-2e9c2f26daaf444dabbf4bcb30935231 |
| Quellennotiz | uspto-grants-2015_03 |