N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide → N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide

HRID 876247

Reaktionsgleichung

Reaktionsgleichung von HRID 876247
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:12]=[N:13][CH:14]=2)=[CH:5][CH:4]=1>C(O)(=O)C>[F:24][C:2]([F:1])([F:25])[C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:23])[CH2:10]2)=[CH:7][CH:8]=1

Komponenten

3

Edukt 1

HCID 66701368N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide

Produkt 1

HCID 66701397N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 1.0 g (2.9 mmol) of N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide in 120 ml of glacial acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. The product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 657 mg (50% pure).

Aufarbeitung

  1. concentrationThe solution was concentrated under reduced pressure
  2. customThe product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient)

Quellen und Nachweise

ORD-Eintrag
ord-2e9c2f26daaf444dabbf4bcb30935231
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987248B2

Verknüpfte Notizen

Wird geladen…