HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Chloro-2-thiophenecarboxylic acid → 5-Chloro-N-[1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]thiophene-2-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Chloro-2-thiophenecarboxylic acid | HCID 95048 | — |
| Edukt | 1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate | HCID 66701344 | — |
| Produkt | 5-Chloro-N-[1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]thiophene-2-carboxamide | HCID 66761704 | — |
Reaktionsschritte
65 mg (0.15 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate (Example 8A) and 22 mg (0.13 mmol, 0.9 eq.) of 5-chlorothiophene-2-carboxylic acid were reacted according to General Method 1. Yield: 43 mg (72% of theory)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08987248B2 |
| Quelldatensatz | uspto-grants-2015_03 |
| ORD ID | ord-55fae705e0bf4f34871c63b546abee94 |
| Quellennotiz | uspto-grants-2015_03 |