Dimethyl-1,3-thiazole-5-carboxylic acid → N-[1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]-2,4-dimethyl-1,3-thiazole-5-carboxamide

HRID 876295

Reaktionsgleichung

Reaktionsgleichung von HRID 876295
FC(F)(F)C(O)=O.[CH:8]1([C:13]([N:15]2[CH2:20][CH:19]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH3:28])=[CH:23][CH:22]=3)[CH2:18][CH:17]([NH2:29])[CH2:16]2)=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]1.[CH3:30][C:31]1[S:32][C:33]([C:37](O)=[O:38])=[C:34]([CH3:36])[N:35]=1>>[CH:8]1([C:13]([N:15]2[CH2:20][CH:19]([C:21]3[CH:22]=[CH:23][C:24]([CH2:27][CH3:28])=[CH:25][CH:26]=3)[CH2:18][CH:17]([NH:29][C:37]([C:33]3[S:32][C:31]([CH3:30])=[N:35][C:34]=3[CH3:36])=[O:38])[CH2:16]2)=[O:14])[CH2:9][CH2:10][CH2:11][CH2:12]1

Komponenten

3

Edukt 2

HCID 736488Dimethyl-1,3-thiazole-5-carboxylic acidHCID 667013441-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate

Produkt 1

HCID 66761399N-[1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]-2,4-dimethyl-1,3-thiazole-5-carboxamide

Versuchsvorschrift

65 mg (0.15 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate (Example 8A) and 21 mg (0.13 mmol, 0.9 eq.) of 2,4-dimethyl-1,3-thiazole-5-carboxylic acid were reacted according to General Method 1. Yield: 43 mg (73% of theory)

Quellen und Nachweise

ORD-Eintrag
ord-f0b58fa1aebb4dda8f9a3438cb639575
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987248B2

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