Hydrochloric Acid → (R)-4-(2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-yloxy)-3,3-dimethylbutane-1,2-diol dihydro chloride

HRID 876499Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 876499
[N:1]1[N:2]=[C:3]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([O:21][CH2:22][C:23]([C@@H:26]4[CH2:30][O:29]C(C)(C)[O:27]4)([CH3:25])[CH3:24])[CH:14]=[C:15]([F:20])[CH:16]=3)[N:11]=2)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:33]>CO>[ClH:33].[ClH:33].[N:1]1[N:2]=[C:3]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([O:21][CH2:22][C:23]([CH3:25])([CH3:24])[C@@H:26]([OH:27])[CH2:30][OH:29])[CH:14]=[C:15]([F:20])[CH:16]=3)[N:11]=2)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67234098(R)-2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropoxy)-6-fluoroquinoline

Produkt 1

HCID 67233773(R)-4-(2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-yloxy)-3,3-dimethylbutane-1,2-diol dihydro chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

(R)-2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropoxy)-6-fluoroquinoline (0.190 g, 0.435 mmol) was added to methanol saturated with HCl and stirred for 30 minutes. The solution was evaporated, DCM was added, and the material triturated and filtered to yield 140 mgs of the desired product as orange solid. MS ESI (+) m/z 397 (M+1) detected.

Aufarbeitung

  1. customThe solution was evaporated
  2. additionDCM was added
  3. customthe material triturated
  4. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-787a7517b821416795892d68957459e5
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987251B2

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