4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride → HCID 67222610, Verbindung

HRID 876575

Reaktionsgleichung

Reaktionsgleichung von HRID 876575
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][O:11][C@H:10]([C@@H:14]([OH:26])[C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=3)=[O:16])[C:9]2=[O:27])=[CH:4][CH:3]=1.Cl[CH2:29][CH2:30][O:31][CH2:32][C:33](O)=[O:34].[Cl-].COC1N=C(OC)N=C([N+]2(C)CCOCC2)N=1>CN(C=O)C>[C:24]([C:21]1[CH:22]=[CH:23][C:18]([NH:17][C:15](=[O:16])[C@H:14]([OH:26])[C@H:10]2[O:11][CH2:12][CH2:13][N:8]([C:5]3[CH:6]=[CH:7][C:2]([N:1]4[CH2:29][CH2:30][O:31][CH2:32][C:33]4=[O:34])=[CH:3][CH:4]=3)[C:9]2=[O:27])=[CH:19][CH:20]=1)#[N:25]

Komponenten

5

Edukt 3

HCID 27340594-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chlorideHCID 109205842-(2-Chloroethoxy)acetic acidHCID 67032877(2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamide

Produkt 1

HCID 67222610HCID 67222610, VerbindungAusbeute 73,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a suspension of compound 26-5 (0.1 g) and 2-chloroethoxy acetic acid (45.4 mg) in DMF (2 mL), was added 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM; 87.7 mg). The reaction mixture was stirred at room temperature overnight. Then, according to the Step 29-1 in synthetic method for EXAMPLE 29, cyclization reaction was pursued to obtain compound 30-1 (90 mg) as a colorless amorphous solid.

Aufarbeitung

  1. customThen, according to the Step 29-1 in synthetic method for EXAMPLE 29, cyclization reaction

Quellen und Nachweise

ORD-Eintrag
ord-f31e4ae7ca28494aa4b4a360e89da4d8
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987242B2

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