Methyl iodide → HCID 67032868, Verbindung

Reaktionsgleichung

[I:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[CH3:13][O:14][C:15](=[O:18])[CH2:16]Br.CI>>[I:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[N:9]2[CH2:16][C:15]([O:14][CH3:13])=[O:18])=[CH:4][CH:3]=1

Komponenten

Edukt 3

HCID 6328Methyl iodide

HCID 60984Methyl bromoacetate

HCID 588514003,4-Dihydro-7-iodo-2(1H)-quinolinone

Produkt 1

HCID 67032868HCID 67032868, Verbindung

Versuchsvorschrift

According to the Step 8-1 in synthetic method for EXAMPLE aa8, 3,4-dihydro-7-iodo-2(1H)-quinolinone (2.12 g) and bromoacetic acid methyl ester (1.10 mL) were used instead of aa7-1 and MeI to obtain compound aa21-1 (2.24 g) as a white amorphous solid.