Ammonia methanol → Thieno[3,2-b]pyridin-2-ylmethanamine
Reaktionsgleichung
Cl[CH2:2][C:3]1[S:11][C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.[NH3:12].CO>>[S:11]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[CH2:2][NH2:12]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
2-(Chloromethyl)thieno[3,2-b]pyridine (C-5) (183 mg, 1 mmol) was dissolved in NH3/methanol (7 N, 10 mL). The resulting mixture was stirred at 50° C. for 16 hours and concentrated. The residue was purified by chromatography. MS (m/z): 165 (M+1)+.
Aufarbeitung
- concentrationconcentrated
- customThe residue was purified by chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-7e8d186b05e7455f8033054b46d16bb3
- Quelldatensatz
- uspto-grants-2015_03
- Patentnummer
- US08987269B2
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