Aluminium lithium hydride → Thieno[3,2-c]pyridin-2-ylmethanol

HRID 876767Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 876767
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10](OC)=[O:11].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[CH2:10][OH:11]

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 22047666Methyl thieno[3,2-c]pyridine-2-carboxylate

Produkt 1

HCID 46784992Thieno[3,2-c]pyridin-2-ylmethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of methyl thieno[3,2-c]pyridine-2-carboxylate (D-2) (15 g, 77.6 mmol) in anhydrous THF (250 mL) was added LiAlH4 (4.42 g, 116.4 mmol) in portions at 0° C. The suspension was stirred at 0° C. for 1 h and then quenched by adding saturated aqueous NH4Cl and filtered. The filtrate was washed with brine and concentrated. The residue was used in the next step without any further purification (10.3 g).

Aufarbeitung

  1. customquenched
  2. additionby adding saturated aqueous NH4Cl
  3. filtrationfiltered
  4. washThe filtrate was washed with brine
  5. concentrationconcentrated
  6. customThe residue was used in the next step without any further purification (10.3 g)

Quellen und Nachweise

ORD-Eintrag
ord-6b7c4c9efd8e46a58e4caeac72e0c018
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987269B2

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