Ethanol → HCID 67305656, Verbindung

HRID 876786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 876786
[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:10]#[N:11])=[CH:2]1.CCO>N.[Ni]>[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH2:10][NH2:11])=[CH:2]1

Komponenten

5

Edukt 2

HCID 702EthanolHCID 21828305Thieno[2,3-b]pyridine-3-carbonitrile

Produkt 1

HCID 67305656HCID 67305656, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 222AmmoniaLösungsmittel

Versuchsvorschrift

To a solution of thieno[2,3-b]pyridine-3-carbonitrile (J-4) (320 mg, 2 mmol) in NH3.EtOH (25 mL) was added Ranye/Ni (about 300 mg). The reaction was degassed with hydrogen and stirred at room temperature for 2 h. Then the mixture was filtered, and the filtrate was concentrated to give the title compound, which was used for next step without purification. MS (m/z): 165 (M+1)+.

Aufarbeitung

  1. customThe reaction was degassed with hydrogen
  2. filtrationThen the mixture was filtered
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-016509b0dd284250a9613f2e44b35017
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987269B2

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