Thionyl Chloride → HCID 58136651, Verbindung
Reaktionsgleichung
[CH:1]1([CH:6]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][N:17]3[C:22](=[O:23])[CH2:21][O:20][C:19]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[N:18]3)=[CH:12][CH:11]=2)[C:7](O)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:32])=O>>[CH:1]1([CH:6]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][N:17]3[C:22](=[O:23])[CH2:21][O:20][C:19]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[N:18]3)=[CH:12][CH:11]=2)[C:7]([Cl:32])=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
At room temperature, 8.9 g (22.68 mmol) of rac-cyclopentyl{-4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetic acid were stirred with 63.6 ml (871.5 mmol) of thionyl chloride for 2 h. The reaction solution was then warmed to 50° C. and stirred for a further 2 h. After the reaction had gone to completion, the reaction solution was freed from the thionyl chloride under reduced pressure. This gave 7.7 g (18.74 mmol, 82% of theory) of the title compound as a colorless oil, which was used without further purification in subsequent reactions.