Thionyl Chloride → [4-(Bromomethyl)phenyl](cyclopentyl)acetyl chloride

HRID 877180Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 877180
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:10](O)=[O:11])=[CH:5][CH:4]=1.S(Cl)([Cl:20])=O>>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:10]([Cl:20])=[O:11])=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 21255101[4-(Bromomethyl)phenyl](cyclopentyl)acetic acid

Produkt 1

HCID 58136560[4-(Bromomethyl)phenyl](cyclopentyl)acetyl chloride

Versuchsvorschrift

246 mg (0.766 mmol) of [4-(bromomethyl)phenyl](cyclopentyl)acetic acid were dissolved in 5 ml of thionyl chloride, and the mixture was stirred at room temperature for 1 h and then at 50° C. for 1 h. The mixture was then concentrated under reduced pressure. This gave 253 mg of the title compound, which was reacted without further purification in the next step.

Aufarbeitung

  1. waitat 50° C. for 1 h
  2. concentrationThe mixture was then concentrated under reduced pressure
  3. customThis gave 253 mg of the title compound, which was reacted without further purification in the next step

Quellen und Nachweise

ORD-Eintrag
ord-c19338cd04614188bb48453fc84ac4d3
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987256B2

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