2-(Trifluoromethyl)benzeneboronic acid → N-Methyl-3,5-bis-trifluoromethyl-N-[4-(2-trifluoromethyl-phenyl)-pyridin-3-yl]-benzamide

HRID 878003

Reaktionsgleichung

Reaktionsgleichung von HRID 878003
Br[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N:8]([CH3:25])[C:9](=[O:24])[C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=1.[F:26][C:27]([F:38])([F:37])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1B(O)O>>[CH3:25][N:8]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:2]=1[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=1[C:27]([F:38])([F:37])[F:26])[C:9](=[O:24])[C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=1

Komponenten

3

Edukt 2

HCID 27343872-(Trifluoromethyl)benzeneboronic acidHCID 86670692N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide

Produkt 1

HCID 86670694N-Methyl-3,5-bis-trifluoromethyl-N-[4-(2-trifluoromethyl-phenyl)-pyridin-3-yl]-benzamide

Versuchsvorschrift

The title compound was prepared in analogy to example 25, from N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 25, intermediate a) and 2-trifluoromethylphenylboronic acid (CAS RN 1423-27-4). Off-white solid (60%). MS (ESI): m/z=493.4 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-f270c865be52425db5c189165097474e
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987307B2

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