(5-Chloro-2-methylphenyl)boronic acid → N-[4-(5-chloro-2-methyl-phenyl)-pyridin-3-yl]-2,2-dimethyl-propionamide

HRID 878067

Reaktionsgleichung

Reaktionsgleichung von HRID 878067
I[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11].[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([CH3:25])=[C:20](B(O)O)[CH:21]=1>CCCCCCC.CCOC(C)=O>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:25])=[C:18]([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[NH:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:17]=1

Komponenten

4

Edukt 2

HCID 2773336(5-Chloro-2-methylphenyl)boronic acidHCID 10447729N-(4-Iodopyridin-3-yl)-2,2-dimethylpropanamide

Produkt 1

HCID 70663288N-[4-(5-chloro-2-methyl-phenyl)-pyridin-3-yl]-2,2-dimethyl-propionamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899848Ethylacetate heptaneLösungsmittel

Versuchsvorschrift

The title compound was prepared in analogy to example 72, from N-(4-iodo-pyridin-3-yl)-2,2-dimethyl-propionamide (CAS RN 113975-32-9) and 5-chloro-2-methylphenylboronic acid (CAS RN 148839-33-2) and using a gradient of n-heptane:EtOAc (100:0 to 0:100). Light yellow solid (99%). MS (ESI): m/z=303.126 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-d620593104e74924b11517bf91f926ed
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987307B2

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