3-Methanesulfonyl-5-(trifluoromethyl)benzoic acid → HCID 70663583, Verbindung
Reaktionsgleichung
[CH:1]1([O:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[NH:17][CH3:18])[CH2:3][CH2:2]1.[CH3:19][S:20]([C:23]1[CH:24]=[C:25]([CH:29]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:31]=1)[C:26]([OH:28])=O)(=[O:22])=[O:21]>>[CH:1]1([O:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[N:17]([CH3:18])[C:26](=[O:28])[C:25]2[CH:29]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:31]=[C:23]([S:20]([CH3:19])(=[O:21])=[O:22])[CH:24]=2)[CH2:3][CH2:2]1Komponenten
3
Versuchsvorschrift
The title compound was prepared in analogy to example 90, from [4-(2-cyclopropoxy-phenyl)-pyridin-3-yl]-methyl-amine and 3-(methylsulfonyl)-5-(trifluoromethyl)benzoic acid (example 114, intermediate a) after a reaction time of 18 hours at room temperature. The compound was purified by silica gel chromatography on a 20 g column using an MPLC (Flashmaster) system eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100). Light yellow foam (65%). MS (ESI): m/z=491.125 [M+H]+.
Aufarbeitung
- customThe compound was purified by silica gel chromatography on a 20 g column
- washeluting with a gradient of n-heptane:EtOAc (100:0 to 0:100)