Potassium bisulfate → 4-{[tert-Butyl(dimethyl)silyl]oxy}butanoic acid

HRID 878621Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 878621
[Si:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]([O:14][Li])=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].OS([O-])(=O)=O.[K+]>C(OCC)(=O)C>[Si:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 516920Potassium bisulfateHCID 178506949HCID 178506949, Verbindung

Produkt 1

HCID 1868234-{[tert-Butyl(dimethyl)silyl]oxy}butanoic acidAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 4-[tert-butyl(dimethyl)silyl]oxybutanoyloxylithium (8.0 g, 35.71 mmol) in ethyl acetate (10 mL), was carefully added KHSO4 (5%) to adjust pH to about 1. It was then extracted with ethyl acetate three times and organic extracts washed with brine and dried with anhydrous NaSO4. The organic extracts were concentrated to give the title compound (7.4 g, 95%). [M+H] Calc'd for C10H22O3Si, 219; Found, 219.

Aufarbeitung

  1. extractionIt was then extracted with ethyl acetate three times and organic extracts
  2. washwashed with brine
  3. dry with materialdried with anhydrous NaSO4
  4. concentrationThe organic extracts were concentrated

Quellen und Nachweise

ORD-Eintrag
ord-6031e919e9a34a09947d5a51c04406eb
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987461B2

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