[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:24]([NH:25]C(=O)C(F)(F)F)=[C:23]([C:32]([N:34]4[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]4)=[O:33])[O:22][C:11]3=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:24]([NH2:25])=[C:23]([C:32]([N:34]4[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]4)=[O:33])[O:22][C:11]3=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])=[CH:4][CH:3]=1A solution of 35 mg of the product of Example 12 dissolved in 1 mL of methanol was treated with 41 mg of K2CO3 at 60° C. for 2 hours. The reaction mixture was then partitioned between EtOAc and water and the organic product was extracted. The extracts were dried (Na2SO4), filtered and evaporated in vacuo to afford to afford the title compound. HPLC/MS: 500.1 (M+1), 502.1 (M+3); Rt=4.51 min.
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