5-Bromo-3-fluoropyridine-2-carbonitrile → HCID 178437984, Verbindung

HRID 879011Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 879011
[Br:1][C:2]1[CH:3]=[C:4](F)[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH2:11]([Mg]Cl)[CH3:12].ClC1C=CC=C(Cl)C=1C[N:19]1C2C(=NC=C(C(O)=O)C=2)C(C)=N1>>[Br:1][C:2]1[CH:3]=[C:4]2[NH:19][N:9]=[C:8]([CH2:11][CH3:12])[C:5]2=[N:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 441966805-Bromo-3-fluoropyridine-2-carbonitrileHCID 681838111-(2,6-dichlorobenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridine-6-carboxylic acidHCID 178461633HCID 178461633, Verbindung

Produkt 1

HCID 178437984HCID 178437984, Verbindung

Versuchsvorschrift

The titled compound (225 mg) as a white solid was prepared from 5-bromo-3-fluoropyridin-2-carbonitrile (201 mg) obtained by the method described in the document (Journal of Organic Chemistry, 2009, Vol. 74, p. 4547) and ethylmagnesium chloride according to the methods of the processes (1) and (2) of Example 153.

Aufarbeitung

  1. customobtained by the method

Quellen und Nachweise

ORD-Eintrag
ord-a90160fa915f486fa7ce01beb295c1c4
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987473B2

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