Hydrogen Peroxide → 2,3-Epoxy-2-methyl-1,4-naphthoquinone

HRID 879020

Reaktionsgleichung

Reaktionsgleichung von HRID 879020
[CH3:1][C:2]1[C:12](=[O:13])[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:4](=[O:5])[CH:3]=1.[OH-:14].[Na+].OO>CO.O>[CH3:1][C:2]12[C:12](=[O:13])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4](=[O:5])[CH:3]1[O:14]2

Komponenten

5

Edukt 3

HCID 784Hydrogen PeroxideHCID 4055MenadioneHCID 14798Sodium Hydroxide

Produkt 1

HCID 858452,3-Epoxy-2-methyl-1,4-naphthoquinoneAusbeute 91,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22242641Methanol--water (1/1)Lösungsmittel

Versuchsvorschrift

Menadione crystalline (1) (5 g, 29.04 mmol, 1 equivalent) and 2 M NaOH (7.26 mL, 14.52 mmol, 0.5 equivalents) are dissolved in a mixture of methanol/water 4:1 (50 mL) at 0-2° C. After stirring at this temperature for 10 minutes, 35% hydrogen peroxide is added (4.2 mL, 43.56 mmol, 1.5 equivalents). Work-up: after 30 minutes at 0° C. the product is extracted with ethyl ether. The organic phase is dried over Na2SO4 and evaporated under reduced pressure. A whitish powder is obtained (5 g, 26.57 mmol). Yield: 91.5%.

Aufarbeitung

  1. extractionafter 30 minutes at 0° C. the product is extracted with ethyl ether
  2. dry with materialThe organic phase is dried over Na2SO4
  3. customevaporated under reduced pressure
  4. customA whitish powder is obtained (5 g, 26.57 mmol)

Quellen und Nachweise

ORD-Eintrag
ord-a7e61bb52da04aeb97d2f2e8f4e6d445
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987503B2

Verknüpfte Notizen

Wird geladen…