Glutathione → S-Nitrosoglutathione

HRID 879903

Reaktionsgleichung

Reaktionsgleichung von HRID 879903
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].[N:21]([O-])=[O:22].[Na+]>Cl>[CH2:6]([C@H:2]([NH2:1])[C:3]([OH:5])=[O:4])[CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][S:13][N:21]=[O:22])=[O:9]

Komponenten

4

Edukt 2

HCID 124886GlutathioneHCID 23668193Sodium Nitrite

Produkt 1

HCID 104858S-NitrosoglutathioneAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

Briefly, to a stirred ice-cold solution of glutathione (GSH) (154 mg, 0.5 mmol) in 5 ml of 0.2 N HCl was added a portion of NaNO2 (35 mg, 0.5 mmol). This reaction gives GSNO in a high yield of more than 80%. The final red solution was protected from light with aluminum foil and stable in the dark, which allow it to be used directly after synthesis without purification.

Quellen und Nachweise

ORD-Eintrag
ord-3ac6cde16d2147d588e8ce949d32b999
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08992945B2

Verknüpfte Notizen

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