Triethylamine → HCID 178523576, Verbindung

HRID 880034

Reaktionsgleichung

Reaktionsgleichung von HRID 880034
[OH:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[CH:6][C:7]=1[C:8](Cl)=[O:9].[C:12]1([C@@H:18]2[CH2:23][CH2:22][C@H:21]([NH2:24])[CH2:20][CH2:19]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.CCN(CC)CC>C(Cl)Cl>[OH:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[CH:6][C:7]=1[C:8]([NH:24][C@H:21]1[CH2:20][CH2:19][C@@H:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:23][CH2:22]1)=[O:9]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 867300873-Hydroxy-2-oxo-1,2-dihydropyridine-4-carbonyl chloride2×HCID 178418405HCID 178418405, Verbindung2×

Produkt 1

HCID 178523576HCID 178523576, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 3-hydroxy-2-oxo-1,2-dihydropyridine-4-carbonyl chloride (Intermediate 17) (38.1 mg, 0.219 mmol) and cis-4-phenylcyclohexanamine (Intermediate 14) (50 mg, 0.29 mmol) in DCM (1 mL) was added Et3N (0.061 mL, 0.44 mmol). The reaction mixture was stirred at rt for 1 h. The reaction mixture was partitioned between H2O and DCM. The DCM layer was dried over Na2SO4 and filtered through a silica gel plug. The solvent was removed under reduced pressure to give Example 36A which was used without further purification.

Aufarbeitung

  1. customThe reaction mixture was partitioned between H2O and DCM
  2. dry with materialThe DCM layer was dried over Na2SO4
  3. filtrationfiltered through a silica gel plug
  4. customThe solvent was removed under reduced pressure
  5. customto give Example 36A which
  6. customwas used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-44906a32281c4353b07466489919940a
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993557B2

Verknüpfte Notizen

Wird geladen…