HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Carbonate → 2,2'-(6-Oxo-1-(1-phenylethyl)-1,6-dihydropyridazine-4,5-diyl)dibenzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | 2-(2-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 3570229 | — |
| Edukt | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Edukt | 4,5-dichloro-2-(1-phenylethyl)pyridazin-3(2H)-one | HCID 68013986 | — |
| Katalysator | Palladium Chloride | HCID 24290 | — |
| Produkt | 2,2'-(6-Oxo-1-(1-phenylethyl)-1,6-dihydropyridazine-4,5-diyl)dibenzonitrile | HCID 57385631 | 3,4% |
Reaktionsschritte
Compound 4 is prepared from the intermediate 1a and 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile according to step 1 of the method of synthesis using PdCl2/2PPh3, Na2CO3 and a mixture of water/acetonitrile: 1/1. The minor product formed corresponds to compound 4 (yield: 3.4%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08993569B2 |
| Quelldatensatz | uspto-grants-2015_03 |
| ORD ID | ord-df0cc13c5705491984ec678e116cfc26 |
| Quellennotiz | uspto-grants-2015_03 |