Hydrochloric Acid → HCID 178497304, Verbindung

HRID 880969Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 880969
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=2)[NH:4][NH:3]1.Cl.[CH3:15]O>>[OH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13][CH3:15])=[O:12])=[CH:8][CH:9]=2)[NH:4][N:3]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 533377172,3-Dihydro-3-oxo-1H-indazole-6-carboxylic acid

Produkt 1

HCID 178497304HCID 178497304, VerbindungAusbeute 100 %

Versuchsvorschrift

3-Oxo-2,3-dihydro-1H-indazole-6-carboxylic acid (1.5 g, 8.4 mmol) was suspended in methanol (17 mL). Concentrated hydrochloric acid (3.1 mL, 101 mmol) was added and the reaction was heated to reflux for 24 hours. The reaction was concentrated to give the title compound (1.6 g, 100%). +ESI (M+H) 193.1; 1H NMR (400 MHz, DMSO-d6, δ): 11.98 (br. s., 1H), 7.89 (s, 1H), 7.72 (d, J=8.6 Hz, 1H), 7.50 (dd, J=8.5, 1.3 Hz, 1H), 3.85 (s, 3H).

Aufarbeitung

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 24 hours
  3. concentrationThe reaction was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-8752cf31145749909a2bac67fe6bd245
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993586B2

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