5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbaldehyde → 5-(4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)furo[3,2-d]pyrimidin-2-yl)pyridine-3-carbaldehyde

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbaldehyde	HCID 4992640	—
Edukt	2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinofuro[3,2-d]pyrimidine	HCID 56833744	—
Produkt	5-(4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)furo[3,2-d]pyrimidin-2-yl)pyridine-3-carbaldehyde	HCID 58234012	—

Reaktionsschritte

2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinofuro[3,2-d]pyrimidine (Example 153) was reacted with 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-3-carbaldehyde via General Procedure E to give, after purification by reverse HPLC, 11 mg of 238. MS (Q1) 487 (M+).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08993563B2
Quelldatensatz	uspto-grants-2015_03
ORD ID	ord-ff0b10725ac34cd8b93d59c38c64d917
Quellennotiz	uspto-grants-2015_03